Craniomandibular osteopathy is a skeletal disease that occurs mainly i
n certain breeds of young terriers and occasionally in nonterrier bree
ds. Although the cause of the disorder is debated, evidence indicates
an autosomal recessive pattern of inheritance in West Highland white t
erriers. Affected dogs usually show signs of mandibular swelling, droo
ling, difficulties in prehension, and pain on opening the mouth. Radio
graphic changes are usually bilateral but can be asymmetric. Biopsy ma
y be advisable to verify atypical cases, such as in rarely affected br
eeds with lesions confined to the mandible, especially if the lesions
are unilateral. Craniomandibular osteopathy is inherited as an autosom
al recessive trait in West Highland white terriers, and a congenital p
redisposition may exist in other terriers. The mandible and the tympan
ic bullae-petrous temporal bone region are commonly affected. The dise
ase is usually nonfatal and self-limiting. Antiinflammatory drug thera
py may help reduce clinical signs.