AN IMPROVED VERSION OF AN OLD FLUOROCARBINOL CHIRAL STATIONARY-PHASE

A chiral stationary phase (CSP) derived from anthrone is quite effecti ve for the chromatographic resolution of the enantiomers of a wide var iety of compounds. Denoted CSP 4, the phase is a chiral 2,2,2-trifluor o-1-(9-anthryl)ethanol tethered to silica by an eleven-carbon-atom cha in at the 10-position of the anthryl ring. CSP 4 typically provides gr eater enantioselectivity than its fluoroalcohol predecessor and is syn thetically much more accessible.