We describe the case of a 60 year old man with primary amyloidosis, wh
o suffered from peripheral neuropathy and cardiomyopathy and who prese
nted with recurrent right pleural effusion. For this reason, he was ad
mitted to hospital for thoracoscopic examination with pleurodesis. Mac
roscopic examination of the parietal pleura revealed a diffuse inflamm
ation and light brown deposits that where covered with nodules. Biopsy
specimens confirmed the amyloid deposition. This macroscopic appearan
ce is described for the first time, and suggests that a local pleural
synthesis of amyloid substance may occur during the course of systemic
amyloidosis.