INFLUENCE OF PUBERTY ON LIPIDS AND LIPOPROTEIN PROFILE IN CHILDREN WITH TYPE-1 DIABETES-MELLITUS

In order to assess whether or not the lipoprotein profile worsens thro ughout puberty in children with type 1 diabetes mellitus and if this c hange is related to dietary compliance, we studied 46 (20 female, 26 m ale) children. At the beginning of the study, the mean age (+/-SD) was 10.9 +/- 1.1 years; all the children studied had reached a pubertal s tage of P1, G1. The mean duration of diabetes (+/-SD) was 4.9 +/- 1.8 years. The diet and the lipoprotein profile of diabetic children were analysed at the beginning of the study and after 6 years. The quality of metabolic control of subjects studied had not changed significantly at the end of the study (haemoglobin HbA(1c) 7.6% +/- 2.1% vs 7.9% +/ - 2.0%; NS). After puberty, the diabetic patients received more energy from carbohydrate and less from lipids. Total serum cholesterol and t riglycerides and levels of low-density Lipoproteins were significantly higher and of high-density lipoproteins lower in the diabetic patient s after puberty than before (4.47 +/- 0.7 mmol/l vs 5.99 +/- 0.6, P<0. 01; 0.90+/-0.02 mmol/l vs 1.45 +/- 0.03, P<0.01; 2.2 +/- 0.3 mmol/l vs 2.8 +/- 0.5, P<0.01; 1.5 +/- 0.2 vs 1.1 +/- 0.2, P < 0.01, respective ly), These results suggest a detrimental effect of puberty on lipoprot eins; probably, dietary compliance plays a role in this worsening. Die tary education should be intensified during adolescence in order to pr esent these changes.