ECTOPIC POSTERIOR PITUITARY TISSUE AND PARACENTRIC INVERSION OF THE SHORT ARM OF CHROMOSOME-1 IN TWINS

Twin boys with hypopituitarism, hypoplasia of the anterior pituitary g land, ectopic posterior pituitary tissue and paracentric inversion of the short arm of chromosome 1 are described. The smooth appearance at the base of the median eminence and the absence of a pituitary stalk a t autopsy in these boys implies that the hypopituitarism resulted from a developmental aberration. It remains to be determined if there is a causal relationship between the chromosome 1 anomaly and hypopituitar ism.