SYNTHESIS OF 2 RADIOFLUORINATED COCAINE ANALOGS USING DISTILLED 2-[F-18]FLUOROETHYL BROMIDE

Authors
WILSON AA DASILVA JN HOULE S
Citation
Aa. Wilson et al., SYNTHESIS OF 2 RADIOFLUORINATED COCAINE ANALOGS USING DISTILLED 2-[F-18]FLUOROETHYL BROMIDE, Applied radiation and isotopes, 46(8), 1995, pp. 765-770
Citations number
35
Categorie Soggetti
Nuclear Sciences & Tecnology","Radiology,Nuclear Medicine & Medical Imaging
Journal title
Applied radiation and isotopes
ISSN journal
09698043 → ACNP
Volume
46
Issue
8
Year of publication
1995
Pages
765 - 770
Database
ISI
SICI code
0969-8043(1995)46:8<765:SO2RCA>2.0.ZU;2-3
Abstract
Two fluorinated congeners of cocaine, 2'-fluoroethyl (1 R-2-exo-3-exo) -8-methyl-3-(4-methylphenyl)-8 -azabicyclo[3.2.1]octane-2-carboxylate (FETT) and its 4-chlorophenyl analogue (FECT) were synthesized. Radiol abelling with F-18 was achieved by O-[F-18]fluoroalkylation of the cor responding carboxylic acid salts with distilled 2-[F-18]fluoroethyl br omide in DMF. After HPLC purification, yields of radiochemically pure, formulated products were 22-30% (not corrected for decay) in a synthe sis time of 60-70 min. The use of distilled 2-[F-18]fluoroethyl bromid e was indispensable for the reliable production of pure products.