Local or regional flaps usually are sufficient for reconstruction of d
efects of the cranial base. In some cases, however, free-tissue transf
er may be the best or the only choice. Reasons for choosing free-tissu
e transfer over other methods of reconstruction include previous radia
tion, previous surgery, Limited are of rotation of pedicle flaps, lowe
r complication and failure rates of free flaps, and specific tissue re
quirements that only can be met with a free flay. The anatomy, availab
le flap choices, indications, and technical considerations applicable
to cranial base reconstruction with microvascular surgery are discusse
d.