SEAVIEW AND PHYLO-WIN - 2 GRAPHIC TOOLS FOR SEQUENCE ALIGNMENT AND MOLECULAR PHYLOGENY

SEAVIEW and PHYLO_WIN are two graphic tools for X Windows-Unix compute rs dedicated to sequence alignment and molecular phylogenetics. SEAVIE W is a sequence alignment editor allowing manual or automatic alignmen t through an interface with CLUSTALW program. Alignment of large seque nces with extensive length differences is made easier by a dot-plot-ba sed routine. The PHYLO_WIN program allows phylogenetic tree building a ccording to most usual methods (neighbor joining with numerous distanc e estimates, maximum parsimony, maximum likelihood), and a bootstrap a nalysis with any of them. Reconstructed trees can be drawn, edited, pr inted, stored, evaluated according to numerous criteria. Taxonomic spe cies groups and sets of conserved regions can be defined by mouse and stored into sequence files, thus avoiding multiple data files. Both to ols are entirely mouse driven. On-line help makes them easy to use.