Tailored surgical antireflux procedures were done in 104 patients duri
ng a 7-year period. Presenting symptoms included heartburn in 95 patie
nts (91%), regurgitation in 83 patients (80%), and dysphagia in 61 pat
ients (60%). Evaluation before operation included video barium esophag
ography, endoscopy, 24-hour esophageal pH monitoring, and esophageal m
otility studies. On the basis of anatomic and functional findings, the
following procedures were performed: 15 laparoscopic and 49 open tran
sabdominal Nissen fundoplications, 23 transthoracic Nissen fundoplicat
ions, seven Belsey partial fundoplications, and 10 Collis gastroplasty
and Belsey partial fundoplications. The severity of symptoms was asse
ssed before and after operation according to a previously published gr
ading score, Eighty-five of the 104 patients (82%) were able to be con
tacted for a follow-up evaluation by means of a standardized questionn
aire. Median length of follow-up was 4 years, with 40 patients having
follow-up beyond 5 years. The tailored operation cured the symptoms of
heartburn in 97%, regurgitation in 91%, and dysphagia in 92%. Ninety-
eight percent of the patients reported that operation had cured their
preoperative symptoms and 93% were satisfied with the outcome of the o
peration. To obtain optimal results, surgical treatment of gastroesoph
ageal reflux disease should be tailored to the patient's anatomic and
functional assessments. For early, uncomplicated disease a transabdomi
nal Nissen fundoplication is done, laparoscopically when expertise exi
sts. Patients with complicated disease should undergo an open antirefl
ux procedure tailored to specific anatomic or functional abnormalities
.