DIFFERENTIAL EXPRESSION OF APOLIPOPROTEIN-D AND PROSTATE-SPECIFIC ANTIGEN IN BENIGN AND MALIGNANT PROSTATE TISSUES

Purpose: To investigate Apolipoprotein-D (Apo-D) and prostate specific antigen (PSA) immunohistochemical staining of nonmalignant and malign ant human prostate tissues. Materials and Methods: Apolipoprotein-D an d PSA immunoreactivity were evaluated by video image analysis in nonma lignant prostates and in 30 stage D-2 prostate cancers. Results: Apoli poprotein-D was detected in all 30 tumors, and the level of staining w as elevated in comparison to age-matched nonmalignant prostates (p <0. 05). In contrast, the level of PSA staining in tumors was less than th at detected in nonmalignant prostates. Conclusions: Apolipoprotein-D i s expressed in normal human prostate. Elevated Apo-D staining is assoc iated with advanced prostate cancer.