CALCITONIN-GENE-RELATED PEPTIDE AND PERIPHERIN IMMUNOREACTIVITY IN NERVE SHEATHS

Authors
BOVE GM LIGHT AR
Citation
Gm. Bove et Ar. Light, CALCITONIN-GENE-RELATED PEPTIDE AND PERIPHERIN IMMUNOREACTIVITY IN NERVE SHEATHS, Somatosensory & motor research, 12(1), 1995, pp. 49-57
Citations number
48
Categorie Soggetti
Neurosciences
Journal title
Somatosensory & motor research → ACNP
ISSN journal
08990220
Volume
12
Issue
1
Year of publication
1995
Pages
49 - 57
Database
ISI
SICI code
0899-0220(1995)12:1<49:CPAPII>2.0.ZU;2-P
Abstract
The intrinsic innervation of rat sciatic nerve sheaths was studied by means of immunohistochemical labeling for calcitonin gene-related pept ide (CGRP) and peripherin. CGRP immunoreactivity (CGRP-IR) and periphe rin immunoreactivity (peripherin-IR) were found in fine nerve fibers i ndependent of nerve sheath vasculature. These findings suggest that a subset of the nervi nervorum may have nociceptive functions, and that this subset is distinct from nerve fibers that innervate the blood ves sels of the nerve sheaths.