Transient transverse folds of the esophageal mucosa as seen by barium
esophagography and on endoscopic examination have been termed ''felini
zation.'' This finding has been considered a normal variant or has bee
n associated with reflux esophagitis. No symptoms have been associated
with its presence. In 280 unselected patients undergoing upper gastro
intestinal endoscopy in our clinic, felinization was identified in 24%
by prospective visual examination. It was not correlated with sex, ag
e, symptom complex, or common coexistent endoscopic findings. These tr
ansverse esophageal folds, although visually interesting, appear to ha
ve no clinical significance. The endoscopist should recognize and diff
erentiate them from fixed or persistent folds that can be associated w
ith mucosal disease.