THE EFFECT OF DROPERIDOL ON OBJECTIVE MARKERS OF PATIENT COOPERATION AND VITAL SIGNS DURING ESOPHAGOGASTRODUODENOSCOPY - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PROSPECTIVE INVESTIGATION
Js. Barthel et al., THE EFFECT OF DROPERIDOL ON OBJECTIVE MARKERS OF PATIENT COOPERATION AND VITAL SIGNS DURING ESOPHAGOGASTRODUODENOSCOPY - A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PROSPECTIVE INVESTIGATION, Gastrointestinal endoscopy, 42(1), 1995, pp. 45-50
We investigated the effect of droperidol on objective markers of coope
ration and vital signs in 140 patients undergoing elective diagnostic
esophagogastroduodenoscopy. Procedure duration and the total doses of
midazolam and meperidine required during the procedure were evaluated
as objective markers of patient cooperation. The droperidol group comp
rised 66 patients and the placebo group 74 patients. Patient and proce
dure characteristics were similar for both groups. Droperidol produced
a 10% reduction in procedure duration. Linear multiple regression mod
eling revealed droperidol to be a significant predictor of procedure d
uration (p =.036). Droperidol significantly reduced midazolam and mepe
ridine requirements (p <.01). Nonetheless, four patients in the droper
idol group received naloxone to reverse prolonged, excessive drowsines
s. Droperidol produced a significant reduction in procedure-associated
increase in pulse rate but did not exacerbate procedure-associated re
duction in mean arterial pressure. Droperidol favorably influences mar
kers of patient cooperation during elective, diagnostic esophagogastro
duodenoscopy. However, the clinical significance of these changes is u
nclear.