THE USE OF MIFEPRISTONE IN COMBINATION WITH MISOPROSTOL FOR 2ND TRIMESTER TERMINATION OF PREGNANCY

Objective: To asses the efficacy and acceptability of a combination of an anti-progesterone and a stable prostaglandin analogue in 100 women undergoing second trimester therapeutic termination of pregnancy. Res ults: Abortion was successfully induced in 98 per cent of women. The m edian induction to abortion interval was 6 hours 40 minutes (range 1'3 0''-23'05''). The placenta was retained in 46 pet cent of women. Seven ty five per cent of patients required narcotic analgesia, 25 per cent were managed as day cases. Conclusion: A combination of mifepristone a nd vaginal misoprostol is an effective and acceptable method for secon d trimester termination of pregnancy.