MUPIROCIN RESISTANCE AND METHICILLIN-RESISTANT STAPHYLOCOCCUS-AUREUS (MRSA)

Mupirocin has become the topical agent of choice for the elimination o f methicillin-resistant Staphylococcus aureus (MRSA) carriage. The inc reased use of this antibiotic has been followed by reports of outbreak s due to MRSA with both low- and high-level resistance. Whilst low-lev el resistance is becoming more widespread, it is unlikely to have a ma jor impact upon current practice. High-level resistance is plasmid bor ne, and although uncommon, can lead to problems with elimination espec ially in an outbreak situation. Alternatives are available but uncerta inty exists as to their efficacy and safety. Any strategy to limit the increase of mupirocin resistance in MRSA should emphasize the importa nce of controlled antibiotic use both for mupirocin and other agents.