DIDANOSINE TREATMENT OF HEMOPHILIC PATIENTS INFECTED WITH HIV

Twenty-six haemophilic patients with advanced HIV infection who had de veloped resistance or intolerance to zidovudine were treated with dida nosine (ddl). 11 patients continue to take ddl at a median time of 14 months from commencement (range 7-18 months). Five of these patients s howed an increase in CD4 lymphocyte count, reaching a maximum at a med ian time of 4 months. Four patients with HIV-related symptoms improved clinically. In general, the CD4 count and clinical improvements were not sustained. 11 patients discontinued ddI after a median of 3 months (range 3 days to 10 months), most commonly due to gastrointestinal si de-effects. No case of pancreatitis or peripheral neuropathy was seen. Six patients, all with very advanced HIV disease, died. HIV-infected haemophilic patients who become resistant or intolerant to zidovudine may derive benefit from ddI, although this is usually transient.