TAXOL ENCAPSULATION IN POLY(EPSILON-CAPROLACTONE) MICROSPHERES

Poly(epsilon-caprolactone) (PCL) microspheres containing taxol were pr epared by the solvent evaporation method and tested for angiogenesis i nhibition using the chick chorioallantoic membrane (CAM) model. Very h igh encapsulation efficiencies (95%) for taxol in PCL microspheres wer e obtained. In vitro release studies showed about 25% of the loaded dr ug was released in 6 weeks from microspheres containing 5% taxol. Stud ies with the CAM showed that taxol released from the microspheres indu ced vascular regression and inhibited angiogenesis.