PATHOMORPHOLOGICAL AND PATHOHISTOLOGICAL CHANGES DUE TO OCHRATOXICOSIS-A IN PIGS

The paper presents the results obtained after experimentally induced o chratoxicosis A in pigs. Five different experiments were performed wit h pigs of 2,5 months average age. The pigs were fed for 28 days with d iets which contained ochratoxin A at 12.3, 5.97, 3.10, 1,06 and 0,29 m g/kg of feed. The kidneys, fiver, stomach and small intestine of the p igs were examined for pathomorphological and pathohistological changes . The results showed ischemia of the kidney and catarh of the stomach and intestine. Pathohistologically, dystrophic changes in the form of opaque swellings were found in kidney tubules and in hepatocytes toget her with an accumulation of serous exudate. Desquamation of glomerular epithelial cells of the kidneys were seen, as well as infiltration of the gastric propria and small intestine with eosinophil leucocytes. T he observed pathomorphological and pathohistological changes were corr elated with the amount of ochratoxin A consumed in the feed.