ALZHEIMERS-DISEASE - ITS IRREVERSIBLE BUT NOT UNTREATABLE

Alzheimer's disease (AD) poses a major clinical challenge because of i ts high prevalence in the aging population, its prolonged course, and the absence of curative treatment. Important advances have recently be en made, however, in the diagnosis of the disease and the elucidation of its neuroscientific basis. Genetic research has identified an allel e of apolipoprotein E that may confer a higher risk of developing AD. In addition, new, possibilities for treatment are being investigated. One drug therapy-tacrine-has been approved, although uncertainty linge rs about its efficacy and safety. In the absence of effective medical treatment, AD is a difficult problem for patients and their families. However, the physician cart help by providing emotional support, sympt om management, and informed counseling.