BONE MASS IN ANDROGEN-INSENSITIVITY SYNDROME - RESPONSE TO HORMONAL REPLACEMENT THERAPY

Citation
M. Munoztorres et al., BONE MASS IN ANDROGEN-INSENSITIVITY SYNDROME - RESPONSE TO HORMONAL REPLACEMENT THERAPY, Calcified tissue international, 57(2), 1995, pp. 94-96
Citations number
15
Categorie Soggetti
Endocrynology & Metabolism
ISSN journal
0171967X
Volume
57
Issue
2
Year of publication
1995
Pages
94 - 96
Database
ISI
SICI code
0171-967X(1995)57:2<94:BMIAS->2.0.ZU;2-K
Abstract
The response of bone mass to long-term treatment with estrogen and pro gesterone in patients with complete androgen-insensitivity syndrome (A IS) is unknown. We report a 17-year-old female patient (karyotype 46 X , Y) with AIS studied during a 4-year period. Bone mineral density (BM D) measured by dual X-ray absorptiometry in lumbar spine and proximal femur was sharply reduced at the initial visit; and remained unchanged during long-term follow-up on hormone replacement therapy with estrog ens and progestin. Bone metabolism markers were all in the normal rang e. The lack of significant increase in BMD highlights the importance o f androgens on bone physiology that cannot be balanced in spite of an appropriate estrogenic milieu.