M. Munoztorres et al., BONE MASS IN ANDROGEN-INSENSITIVITY SYNDROME - RESPONSE TO HORMONAL REPLACEMENT THERAPY, Calcified tissue international, 57(2), 1995, pp. 94-96
The response of bone mass to long-term treatment with estrogen and pro
gesterone in patients with complete androgen-insensitivity syndrome (A
IS) is unknown. We report a 17-year-old female patient (karyotype 46 X
, Y) with AIS studied during a 4-year period. Bone mineral density (BM
D) measured by dual X-ray absorptiometry in lumbar spine and proximal
femur was sharply reduced at the initial visit; and remained unchanged
during long-term follow-up on hormone replacement therapy with estrog
ens and progestin. Bone metabolism markers were all in the normal rang
e. The lack of significant increase in BMD highlights the importance o
f androgens on bone physiology that cannot be balanced in spite of an
appropriate estrogenic milieu.