CHANGES IN SERUM CARBOXYTERMINAL TELOPEPTIDE OF TYPE-I COLLAGEN IN ANEXPERIMENTAL-MODEL OF CANINE OSTEOMYELITIS

Blood biochemical indices of bone turnover were followed up for 1 mont h in six dogs with experimental osteomyelitis. The bone infection resu lted in significant increase in parameters of bone formation (serum bo ne alkaline phosphatase and serum osteocalcin) and bone resorption [se rum carboxyterminal telopeptide of type I collagen (i-ICTP)] as early as the end of the second week after the operation and inoculation. The re was strong evidence that serum i-ICTP levels could be useful for th e early diagnosis of postoperative complications in veterinary orthope dics, such as posttraumatic osteomyelitis.