A RABBIT TOOTH-PULP ASSAY TO QUANTIFY EFFICACY AND DURATION OF ANTINOCICEPTION BY LOCAL-ANESTHETICS INFILTRATED INTO MAXILLARY TISSUES

Authors
THUT PD TURNER MD CORDES CT WYNN RL
Citation
Pd. Thut et al., A RABBIT TOOTH-PULP ASSAY TO QUANTIFY EFFICACY AND DURATION OF ANTINOCICEPTION BY LOCAL-ANESTHETICS INFILTRATED INTO MAXILLARY TISSUES, Journal of pharmacological and toxicological methods, 33(4), 1995, pp. 231-236
Citations number
20
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Journal of pharmacological and toxicological methods → ACNP
ISSN journal
10568719
Volume
33
Issue
4
Year of publication
1995
Pages
231 - 236
Database
ISI
SICI code
1056-8719(1995)33:4<231:ARTATQ>2.0.ZU;2-V
Abstract
The rabbit tooth-pulp assay is well established as a method for measur ing the efficacy and potency of parenteral analgesic drugs. We describ e a method for administration of local anesthetic drugs into the maxil lary arch and subsequent measurements of antinociceptive action. It wa s possible to use two different methods of ED50 estimation and to prov ide measures of the potency, efficacy, and duration of local anestheti c drugs. These measurements corresponded with in vitro estimates of po tency and duration and with intrinsic observations of the clinical act ions.