Objectives: To determine the incidence, risk factors, and mortality ra
te of gastrointestinal complications in patients with acute spine inju
ry and to derive methods by which mortality can be reduced. Design: Ca
se series. Setting: Regional tertiary care center. Patients: Consecuti
ve sample of 1952 patients with acute spine injury with complete medic
al records who were admitted from 1981 through 1990. Main Outcome Meas
ures: Gastrointestinal tract complications, age, sex, time from injury
to admission, cause of injury, level of spine injury, neurologic defi
cit, head injury, injury to other organ systems, incidence of surgical
intervention for spine injury, length of hospital stay, and mortality
rate. Results: The incidence of gastrointestinal complications was 1.
9%. Gastrointestinal hemorrhage was the most frequent complication. Ri
sk factors for gastrointestinal complications were increasing age (P<.
02), male sex (P<.01), injury to other organ systems (P<.02), head inj
ury (P<.02), cervical spine injury (P<.02), and neurologic deficit (P<
.005). The mortality rate was 19% in patients with gastrointestinal co
mplications, significantly greater (P<.005) than the 2.9% rate in pati
ents without gastrointestinal complications. Conclusions: Gastrointest
inal complications after acute spine injury are uncommon but frequentl
y lethal. Prophylaxis against hemorrhage and earlier diagnosis and sur
gical intervention are recommended.