Sabeluzole, a new benzothiazol derivative, has shown positive effects
on memory function in animals and in normal volunteers. The present st
udy reports the results of sabeluzole, in memory-impaired patients wit
h localization-related (partial) epilepsy, A randomized, double-blind
placebo-controlled parallel-group design was used. A total of 38 patie
nts entered a prospective baseline, Five patients dropped out from the
study, thus 33 patients were randomly assigned to either a 12-weeks t
reatment with sabeluzole (n = 14) or placebo (n = 19). The treatment p
hase was preceded by a titration phase of 4 weeks to obtain serum leve
ls of sabeluzole between 50 and 130 ng/ml. In order to maintain blindn
ess, a sham titration was carried out in the placebo group. The number
of 'responders', i,e. patients with a >1 SD improvement on at least t
hree of the memory tests was 9 out of 14 (64, 3 %) in the sabeluzole g
roup and 7 out of 19 (36.8%) in the placebo group. This suggests a cli
nically relevant effect of sabeluzole. The analysis of the memory test
s showed a statistically significant improvement with sabeluzole on th
e verbal long-term memory test, This could represent a specific drug e
ffect and is in line with previous results of normal volunteer studies
that also found improvement mainly restricted to the area of verbal l
ong-term memory.