SYNTHESIS AND ANTIMICROBIAL ACTIVITY OF BRIDGEHEAD NITROGEN-HETEROCYCLES - REACTIONS OF 3-N-METHYL IPERIDINO-4-AMINO-5-MERCAPTO-4(H)-1,2,4-TRIAZOLES/

The reactions of piperidino-4-amino-5-mercapto-4(H)-1,2,4-triazoles (1 a-f) with various aliphatic/aromatic acids (2a-f-10a-f), cyanogen brom ide (11a-f), carbon disulphide (12a-f), alpha-haloketones (13a-f-14a-f ), benzoin (15a-f), dimedone (16a-f), chloroacetic acid (17a-f), hydra zine hydrate (18a-f) and methyl iodide (19a-f) are described. The char acterisation of products has been done on the basis of elemental analy sis, IR, NMR and mass spectral data. All the newly synthesised compoun ds have been screened for antimicrobial activity against bacteria S. a ureus, E. coli and fungi C. albicans, A. averanthus. Results of antimi crobial screening have shown that compounds having 3-N-methyl/ethyl/(a lpha-methyl)ethylpiperidino moiety at position-3 of 1,2,4-triazole nuc leus exhibit significant antifugal activity against both the fungal st rains.