SYNTHESIS OF 4'-FLUOROADENOSINE AS AN INHIBITOR OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE

Authors
GUILLERM D MUZARD M ALLART B GUILLERM G
Citation
D. Guillerm et al., SYNTHESIS OF 4'-FLUOROADENOSINE AS AN INHIBITOR OF S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE, Bioorganic & medicinal chemistry letters, 5(14), 1995, pp. 1455-1460
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
14
Year of publication
1995
Pages
1455 - 1460
Database
ISI
SICI code
0960-894X(1995)5:14<1455:SO4AAI>2.0.ZU;2-K
Abstract
Synthesis of 4'-Fluoroadenosine was achieved via N-6-benzoyl-9-(5-deox y-2, benzoyl-beta-D-erythro-pent-4-enofuranosyl)adenine as intermediat e. Evaluation of its inhibitory effect on S-adenosyl-L-homocysteine hy drolase exhibited interesting properties. 4'-Fluoroadenosine caused a time-dependent inactivation of the enzyme, this inactivation was accom panied by reduction of the enzyme-bound NAD(+)(ENAD+) to NADH.