DESIGN AND SYNTHESES OF 4-ACYLAMINOPYRIDINE DERIVATIVES - NOVEL HIGH-AFFINITY CHOLINE UPTAKE ENHANCERS .1.

Authors
CHAKI H YAMABE H SUGANO M MORITA S BESSHO T TABATA R SAITO KI EGAWA M TOBE A MORINAKA Y
Citation
H. Chaki et al., DESIGN AND SYNTHESES OF 4-ACYLAMINOPYRIDINE DERIVATIVES - NOVEL HIGH-AFFINITY CHOLINE UPTAKE ENHANCERS .1., Bioorganic & medicinal chemistry letters, 5(14), 1995, pp. 1489-1494
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
14
Year of publication
1995
Pages
1489 - 1494
Database
ISI
SICI code
0960-894X(1995)5:14<1489:DASO4D>2.0.ZU;2-J
Abstract
4-Acylaminopyridine derivatives were synthesized and found to have hig h affinity choline uptake improvement activity. Optimum activity was o btained when the n-propylcarbonyl group was introduced as the acyl moi ety. A series of 2-oxo-1-pyrrolidineacetyl substituted derivatives als o showed activity.