DESIGN AND SYNTHESES OF 4-ACYLAMINOPYRIDINE DERIVATIVES - NOVEL HIGH-AFFINITY CHOLINE UPTAKE ENHANCERS .2.

Authors
CHAKI H YAMABE H SUGANO M MORITA S BESSHO T TABATA R SAITO KI EGAWA M TOBE A MORINAKA Y
Citation
H. Chaki et al., DESIGN AND SYNTHESES OF 4-ACYLAMINOPYRIDINE DERIVATIVES - NOVEL HIGH-AFFINITY CHOLINE UPTAKE ENHANCERS .2., Bioorganic & medicinal chemistry letters, 5(14), 1995, pp. 1495-1500
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
14
Year of publication
1995
Pages
1495 - 1500
Database
ISI
SICI code
0960-894X(1995)5:14<1495:DASO4D>2.0.ZU;2-K
Abstract
The syntheses of 4-acylaminopyridine derivatives and their high affini ty choline uptake improvement activities are described. N-propylcarbon yltetrahydroaminoacridine (1) was selected as a lead compound. Modific ation of its ring structure and acyl moiety led some active compounds. Among them, 9d (MKC-231) showed the highest activity. This compound i s expected to be a unique medicine for Alzheimer's disease.