PEPTIDYL ALDEHYDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF CATHEPSIN-L

Authors
WOO JT SIGEIZUMI S YAMAGUCHI K
Citation
Jt. Woo et al., PEPTIDYL ALDEHYDE DERIVATIVES AS POTENT AND SELECTIVE INHIBITORS OF CATHEPSIN-L, Bioorganic & medicinal chemistry letters, 5(14), 1995, pp. 1501-1504
Citations number
25
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
14
Year of publication
1995
Pages
1501 - 1504
Database
ISI
SICI code
0960-894X(1995)5:14<1501:PADAPA>2.0.ZU;2-9
Abstract
A series of peptidyl aldehyde derivatives were synthesized and tested for their inhibitory effects on several cysteine proteases and a serin e protease. These componds showed no inhibition for alpha-chymotrypsin at the concentration less than 1000 ng/ml, while they exhibited promi nent inhibition for calpain II and cathepsins, especially cathepsin L.