APORPHINE ALKALOIDS, CD45 PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS, FROM ROLLINIA-ULEI

Authors
MISKI M SHEN X COOPER R GILLUM AM FISHER DK MILLER RW HIGGINS TJ
Citation
M. Miski et al., APORPHINE ALKALOIDS, CD45 PROTEIN-TYROSINE-PHOSPHATASE INHIBITORS, FROM ROLLINIA-ULEI, Bioorganic & medicinal chemistry letters, 5(14), 1995, pp. 1519-1522
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
14
Year of publication
1995
Pages
1519 - 1522
Database
ISI
SICI code
0960-894X(1995)5:14<1519:AACPIF>2.0.ZU;2-Z
Abstract
Using a high throughput colorimetric bioassay three aporphine alkaloid s, annonaine, nornuciferine and roemerine, were isolated and identifie d as the CD45 protein tyrosine phosphatase inhibitor metabolites of Ro llinia ulei. The nor-aporphine alkaloids, anonaine (1) and nornuciferi ne (3), exhibited more potent inhibitory activity than that of the N-m ethylated alkaloid roemerin (2).