A case of diltiazem overdose with significant hemodynamic compromise i
s presented. Multiple therapeutic modalities were attempted with limit
ed results. Control was finally achieved with a combination of norepin
ephrine, dobutamine, and cardiac pacing. Invasive pulmonary monitoring
parameters are reported and were important in the management of this
patient. The management of calcium channel blocker overdose and the va
rious available therapeutic modalities are discussed. (C) 1995 by W.B.
Saunders Company