SYNTHESIS OF A RATIONALLY DESIGNED INHIBITOR OF THE (S)-ADENOSYL-L-METHIONINE - DELTA-24(25)-STEROL METHYL TRANSFERASE

Authors
GUO DA NES WD
Citation
Da. Guo et Wd. Nes, SYNTHESIS OF A RATIONALLY DESIGNED INHIBITOR OF THE (S)-ADENOSYL-L-METHIONINE - DELTA-24(25)-STEROL METHYL TRANSFERASE, Synthetic communications, 25(17), 1995, pp. 2623-2630
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
25
Issue
17
Year of publication
1995
Pages
2623 - 2630
Database
ISI
SICI code
0039-7911(1995)25:17<2623:SOARDI>2.0.ZU;2-5
Abstract
A facile preparation of the first bisubstrate analog 4,4-dimethyl 14 a lpha-methyl 24(R,S)-OMe, 25-dimethyl amino cholest-8-en-3 beta-ol 3 de signed to interfere with the binding of (S)-adenosyl-L-methionine and of the natural sterol substrate to the (S)-adenosyl-L-methionine: Delt a(24(25))-sterol methyl transferase is reported here. Confirmation of the identity of the novel side chain modified N-sterol was obtained by H-1- and C-13-NMR.