REGULATION OF PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA IN MONOCYTES STIMULATED BY THE 30-KILODALTON ANTIGEN OF MYCOBACTERIUM-TUBERCULOSIS

Authors
AVERILL L TOOSSI Z AUNG H BOOM WH ELLNER JJ
Citation
L. Averill et al., REGULATION OF PRODUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA IN MONOCYTES STIMULATED BY THE 30-KILODALTON ANTIGEN OF MYCOBACTERIUM-TUBERCULOSIS, Infection and immunity, 63(8), 1995, pp. 3206-3208
Citations number
15
Categorie Soggetti
Immunology,"Infectious Diseases
Journal title
Infection and immunity → ACNP
ISSN journal
00199567
Volume
63
Issue
8
Year of publication
1995
Pages
3206 - 3208
Database
ISI
SICI code
0019-9567(1995)63:8<3206:ROPOTI>2.0.ZU;2-S
Abstract
The 30-kDa secreted antigen of Mycobacterium tuberculosis was a strong inducer of tumor necrosis factor alpha in human monocytes. Our findin gs suggest that tumor necrosis factor alpha production mag be up-regul ated at both the posttranscriptional and transcriptional levels. Regul ation at the posttranscriptional level probably reflects enhanced tran slational efficiency.