LIPOPOLYSACCHARIDE TREATMENT IN-VIVO INDUCES TISSUE EXPRESSION OF GTPCYCLOHYDROLASE-I MESSENGER-RNA

Authors
HATTORI Y OKA M KASAI K NAKANISHI N SHIMODA SI
Citation
Y. Hattori et al., LIPOPOLYSACCHARIDE TREATMENT IN-VIVO INDUCES TISSUE EXPRESSION OF GTPCYCLOHYDROLASE-I MESSENGER-RNA, FEBS letters, 368(2), 1995, pp. 336-338
Citations number
22
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
368
Issue
2
Year of publication
1995
Pages
336 - 338
Database
ISI
SICI code
0014-5793(1995)368:2<336:LTIITE>2.0.ZU;2-5
Abstract
A significant induction of GTP cyclohydrolase I (GTPCH) mRNA was obser ved in lung, heart and kidney of rats treated with Lipopolysaccharide (LPS; 10 mg/kg i.v.). GTPCH mRNA levels in liver were high even in unt reated rats, and remained elevated after LPS treatment. Parallel induc tion of nitric oxide synthase (NOS) mRNA was observed in these tissues of LPS-treated rats. Our results demonstrate induction of GTPCH mRNA after LPS treatment in vivo and provide molecular evidence for the inc reased GTPCH activity which may up-regulate NOS activity in vivo.