EFFECTS OF DELTA-SLEEP-INDUCING PEPTIDE (DSIP) AND SOME ANALOGS ON THE ACTIVITY OF MONOAMINE-OXIDASE TYPE-A IN RAT-BRAIN UNDER HYPOXIA STRESS

Authors
KHVATOVA EM RUBANOVA NA PRUDCHENKO IA MIKHALEVA II
Citation
Em. Khvatova et al., EFFECTS OF DELTA-SLEEP-INDUCING PEPTIDE (DSIP) AND SOME ANALOGS ON THE ACTIVITY OF MONOAMINE-OXIDASE TYPE-A IN RAT-BRAIN UNDER HYPOXIA STRESS, FEBS letters, 368(2), 1995, pp. 367-369
Citations number
20
Categorie Soggetti
Biophysics,Biology
Journal title
FEBS letters → ACNP
ISSN journal
00145793
Volume
368
Issue
2
Year of publication
1995
Pages
367 - 369
Database
ISI
SICI code
0014-5793(1995)368:2<367:EODP(A>2.0.ZU;2-6
Abstract
Metabolic effects of delta-sleep inducing peptide (DSIP) under hypoxia stress were investigated in rats subjected to short-term hypoxic cond itions (about 0.26 Bar). It was found that DSIP partially restricted s tress-induced changes in activity of mitochondrial monoamine oxidase t ype A (MAO-A) and serotonin level in rat brain, A number of DSIP analo gues was tested and among them there were some compounds with enhanced ability to counteract hypoxia induced changes in MAO-A activity and s erotonin content in comparison with native neuropeptide.