REDUCTIVE ALKYLATION OF 9-AMINO-XANTHEN-3-YLOXYMETHYLPOLY(STYRENE) - A NOVEL PROCEDURE FOR THE SYNTHESIS OF PEPTIDYL N-ALKYL AMIDES BY FMOCBU(T) CHEMISTRY/

Reductive N-alkylation of the 'amide' anchor resin, 9-amino-xanthen-3- yloxymethyl poly(styrene) 1, by sequential treatment with alkyl aldehy des under mild acidic conditions followed by NaBH4 in MeOH-DMF, and th en followed by optimised Fmoc/Bu(t) solid-phase peptide synthetic proc edures afforded an unique class of peptidyl N-alkyl amides in excellen t yields.