Our objective was to determine whether repeat Pap smears obtained at c
olposcopy with tissue sampling yield useful information. A retrospecti
ve study of 314 women who underwent colposcopy with both Pap smear and
tissue sampling was performed. The colposcopic Pap smear diagnoses we
re compared with the concomitant tissue and prior Pap smear diagnoses,
and discrepant cases were reviewed. The repeat colposcopic Pap smear
yielded a more serious diagnosis than the tissue or prior Pap smear in
only 8 cases. All differences were within one Bethesda system categor
y. The clinical management of these patients was not significantly alt
ered by the colposcopic Pap smear diagnosis. These Pap smears represen
ted 7.1% of the total Pap smears and 30% of the abnormal Pap smears ex
amined by the cytology laboratory during the study period. The estimat
ed Medicare reimbursement for evaluating these smears ranges from $620
0 to $7800. Repeat colposcopic Pap smears add to the cost of a colposc
opic workup but offer only limited clinical benefit.