The isolated, extracellular fibrils of the myxobacterium, Myxococcus x
anthus, are capable of carrying out ADP-ribosylation. The substrate fo
r the ADP-ribosylation is reactive with monoclonal antibody 2105, whic
h has been shown to be directed specifically against the integral fibr
il proteins. The extracellular fibrils thus contain both the ADP-ribos
yl transferase and the substrate for the ribosylation. This process ma
y play a role in the contact-mediated cell-cell interactions that are
an important part of the social behaviour of M. xanthus.