TRANSFORMING GROWTH-FACTOR-ALPHA EXPRESSION IN IN-SITU EPIDERMAL NEOPLASIA

Authors
GRANT JJH HOWES G MCKEE PH
Citation
Jjh. Grant et al., TRANSFORMING GROWTH-FACTOR-ALPHA EXPRESSION IN IN-SITU EPIDERMAL NEOPLASIA, Clinical and experimental dermatology, 20(3), 1995, pp. 208-212
Citations number
21
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
Clinical and experimental dermatology → ACNP
ISSN journal
03076938
Volume
20
Issue
3
Year of publication
1995
Pages
208 - 212
Database
ISI
SICI code
0307-6938(1995)20:3<208:TGEIIE>2.0.ZU;2-B
Abstract
Twenty cases of solar keratosis and 15 cases of Bowen's disease were i nvestigated for the expression of transforming growth factor alpha (TG F-alpha) by an indirect immunoperoxidase technique using monoclonal an tibody TGF-alpha AB-2 in formalin-fixed wax-embedded tissue. Twelve ca ses (60%) of solar keratosis and 13 cases (86%) of Bowen's disease sho wed marked overexpression of TGF-alpha in both membranous and cytoplas mic distributions. This suggests that overexpression of TGF-alpha may play an important role in the evolution of these two neoplastic condit ions.