BULLOSIS DIABETICORUM - A CASE-REPORT AND LITERATURE-REVIEW

We report a case of bullosis diabeticorum with blisters confined to th e lower legs and feet. Histology of a lesion demonstrated a bulla at t he dermo-epidermal junction, and ultrastructural studies confirmed the split to be at the level of the lamina lucida which we propose is the site of the pathology in this condition. Immunofluorescence studies w ere negative, excluding an immunobullous disease. We postulate that in our patient a combination of increased venous pressure and poor vascu lar supply in diabetic skin, led to the blister formation. The literat ure on this condition is reviewed.