We report the case of a 26-year-old man affected by a symmetrical kera
toderma localized to the interdigital spaces of the fingers. No occupa
tional, traumatic, or irritant factors were discovered. Clinical and h
istological features were consistent with the diagnosis of symmetrical
interdigital hyperkeratosis, a sporadic disorder described by Frei in
1926. We believe this condition to be less rare than the few cases re
ported in the literature would suggest.