STEREOCHEMISTRY AND BIOCHEMICAL APPLICATIONS OF COORDINATION-COMPOUNDS OF MO(VI) WITH OXYGEN AND NITROGEN DONOR LIGANDS

Recent developments in the chemistry of azomethines of molybdenum(VI) are described. A range of interesting phenomena such as octahedral geo metry, coordination sites and biochemical applications, are shown to f ollow from the imposition of ligand oxomolybdenum interaction in these coordination compounds. The ligands used in the present account were derived by the condensation of [1-(2-Naphthenyl)ethanone] and [1-(2-Th ienyl)ethanone] with Hydrazinecarboxamide, Hydrazinecarbothioamide and 2-Aminobenzenethiol. The monomeric complexes were obtained by the bim olar reactions of Dioxobis(2,4-pentanedionato-O,O') molybdenum(VI) wit h these monobasic bidentate oxygen/sulfur and nitrogen chelating agent s. The new products with octahedral geometry have been characterized b y elemental analyses, molecular weight determinations and spectral stu dies viz., i.r. and n.m.r. (H-1 and C-13). To assess the growth inhibi ting potential of the ligands and their dioxomolybdenum(Vl) complexes, the in vitro fungicidal and bactericidal activities have been underta ken. The testicular morphology, testicular sperm density, sperm motili ty, density of cauda epididymal spermatozoa and fertility in mating tr ails and biochemical parameters of reproductive organs with 2-[1-(2-Th ienyl)ethyledene] hydrazinecarbothioamide and its dioxomolybdenum(VI) complex, in vivo has also been described in the present communication.