INVESTIGATIONS ON THE ACUTE TOXICITY OF ACIDIC AND BASIC TRIAMTERENE DERIVATIVES

Authors
PRIEWER H WOLF E ULLRICH F NETZER T VOLLMER G MUTSCHLER E
Citation
H. Priewer et al., INVESTIGATIONS ON THE ACUTE TOXICITY OF ACIDIC AND BASIC TRIAMTERENE DERIVATIVES, Die Pharmazie, 50(6), 1995, pp. 419-421
Citations number
28
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
50
Issue
6
Year of publication
1995
Pages
419 - 421
Database
ISI
SICI code
0031-7144(1995)50:6<419:IOTATO>2.0.ZU;2-F
Abstract
Acidic and basic triamterene derivatives were evaluated with respect t o their acute toxicity. After single intravenous application in mice, derivatives with a basic side-chain were much more toxic than compound s with an acidic side-chain. There is a significant correlation betwee n the potassium retaining properties (measured as ED(50)) and the acut e toxicity (measured as LD(50)) of the substances. The low acute toxic ity after oral application of the compounds can be explained by their low oral bioavailability.