TIME-COURSE AND INHIBITION OF STAVAROSIDE-K, VERATRAMIN AND CERVINEINDUCED HEMOLYSIS BY OTHER PREGNANE GLYCOSIDES AND VERATRUM ALKALOIDS

Authors
BADRIA FA MCCHESNEY JD HALIM AF ZAGHLOUL AM ELSAYED KA
Citation
Fa. Badria et al., TIME-COURSE AND INHIBITION OF STAVAROSIDE-K, VERATRAMIN AND CERVINEINDUCED HEMOLYSIS BY OTHER PREGNANE GLYCOSIDES AND VERATRUM ALKALOIDS, Die Pharmazie, 50(6), 1995, pp. 421-423
Citations number
7
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Die Pharmazie → ACNP
ISSN journal
00317144
Volume
50
Issue
6
Year of publication
1995
Pages
421 - 423
Database
ISI
SICI code
0031-7144(1995)50:6<421:TAIOSV>2.0.ZU;2-0
Abstract
Stavaroside K, veratramine and cevine induce hemolysis, whereas 7 othe r pregnane stavarosides and 8 Veratrum alkaloids are not hemolytic. On the other hand, erythrocytes pretreated or incubated with low concent rations of stavarosides D-F or with the 8 other Veratrum alkaloids wer e resistant to hemolysis induced by authentic saponin, stavaroside K, cevine or veratramine. Veratridine, zygadenine and angeloylzygadenine (the known Na-Channel-Gate toxins) revealed the most potent reduction of hemolytic activity.