EFFECT OF TRAPENCAINE AND SOME OF ITS DERIVATIVES ON GASTRIC WALL MUCUS IN STRESSED RATS

The effect of selected carbanilates on the rat gastric mucus was teste d after oral administration. The compounds K 1905 and K 2002 were foun d to increase gastric mucus content in nonstressed rats while compound P 2 was ineffective. The activity of K 1905 was comparable with that of the parent drug trapencaine. Cold-restraint stress decreased the ga stric mucus content and induced haemorrhagic erosions in the glandular stomach. With the exception of compound P 2 pretreatment with carbani lates dose-dependently diminished the extent of stress-induced gastric damage and prevented the depletion of mucus after stress. The results indicate that pentyloxy-substitution in the meta and in the para posi tion on the benzene ring of the parent structure (K 1905 and K 2002, r espectively) seems to be more suitable for mucus enhancing activity th an alkyloxy-substitution on the para position (P 2). The observed incr eased mucus secretion might be partly responsible for the gastroprotec tive action of the drugs tested.