PREVENTION BY THE CANNABINOID ANTAGONIST, SR141716A, OF CANNABINOID-MEDIATED BLOCKADE OF LONG-TERM POTENTIATION IN THE RAT HIPPOCAMPAL SLICE

Incubation of rat hippocampal slices in the presence of the synthetic cannabinoid (-)-11-OH-Delta(8)-dimethylheptyl tetrahydrocannabinol (HU -210) (100 nM) prevented the induction of long-term potentiation (LTP) . Slices co-incubated with both HU-210 (100 nM) and the cannabinoid an tagonist, SR141716A (100 nM), exhibited tetanically induced LTP, compa rable to control slices. Intriguingly, coincubation with HU-210 and SR 141716A prevented the induction of the early, short-term phase of LTP.