THERAPEUTIC REGIMENS IN ACUTE EXPERIMENTAL PANCREATITIS IN RATS - EFFECTS OF A PROTEASE INHIBITOR, A BETA-AGONIST, AND ANTIBIOTICS

The osmolality of contrast injected retrograde into the rat pancreatic duct did not affect the severity of the pancreatitis (Urografin, 1,30 0 mOsm/kg, and Hexabrix, 580 mOsm/kg). The severity of the pancreatiti s induced in rats was assessed by survival rate, histologic grading, w et lung ratio, and serum levels of amylase, lipase, and trypsin-like a ctivity. Rats with pancreatitis induced by retrograde injected Urograf in, lipopolysaccharide, taurocholic acid plus enterokinase were treate d with either intravenous (i.v.) FUT-175 (Nafamstat Mesilate), FUT-175 administered by retrograde pancreatic injection, i.v. terbutaline, i. v. piperacillin sodium, piperacillin sodium by retrograde pancreatic d uct injection, or a combination of FUT-175 plus terbutaline and pipera cillin. Survival among the rats was increased and the incidence of pan creatic infection reduced in rats treated with i.v. piperacillin or wi th a combination of FUT-175 plus i.v. terbutaline, plus i.v. piperacil lin compared to controls.