REVERSION OF MALIGNANT PHENOTYPE BY 5-IODO-6-AMINO-1,2-BENZOPYRONE A NONCOVALENTLY BINDING LIGAND OF POLY(ADP-RIBOSE) POLYMERASE

Authors
BAUER PI KIRSTEN E VARADI G YOUNG LJT HAKAM A COMSTOCK JA KUN E
Citation
Pi. Bauer et al., REVERSION OF MALIGNANT PHENOTYPE BY 5-IODO-6-AMINO-1,2-BENZOPYRONE A NONCOVALENTLY BINDING LIGAND OF POLY(ADP-RIBOSE) POLYMERASE, Biochimie, 77(5), 1995, pp. 374-377
Citations number
4
Categorie Soggetti
Biology
Journal title
Biochimie → ACNP
ISSN journal
03009084
Volume
77
Issue
5
Year of publication
1995
Pages
374 - 377
Database
ISI
SICI code
0300-9084(1995)77:5<374:ROMPB5>2.0.ZU;2-#
Abstract
A non-covalently binding inhibitory ligand of poly(ADP-ribose) polymer ase, 5-iodo-6-amino-1,2-benzopyrone, when incubated at 5600 mu M exter nal concentration with an E-ras transformed tumorigenic cell line or w ith human prostatic carcinoma cells for 40 to 60 days converts both ca ncer cells to a non-tumorigenic phenotype that is characterized by dra stic changes in cell morphology, absence of tumorigenicity in nude mic e, and a high rate of aerobic glycolysis.