ASYMMETRIC REDUCTION OF 2-(N-ARYLIMINO)-3,3,3-TRIFLUOROPROPANOIC ACID-ESTERS LEADING TO CHIRAL 3,3,3-TRIFLUOROALANINE AND ITS DERIVATIVES

Authors
SAKAI T YAN FY UNEYAMA K
Citation
T. Sakai et al., ASYMMETRIC REDUCTION OF 2-(N-ARYLIMINO)-3,3,3-TRIFLUOROPROPANOIC ACID-ESTERS LEADING TO CHIRAL 3,3,3-TRIFLUOROALANINE AND ITS DERIVATIVES, Synlett, (7), 1995, pp. 753-754
Citations number
14
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
7
Year of publication
1995
Pages
753 - 754
Database
ISI
SICI code
0936-5214(1995):7<753:ARO2A>2.0.ZU;2-B
Abstract
(R)-3,3,3-Trifluoroalanine and its derivatives have been synthesized e nantioselectively by the asymmetric reduction of 2-(N-arylimino)-3,3,3 -trifiuoropropanoic acid esters with (S)-oxazaborolidine-catecholbora ne system. The absolute configuration was determined to be R by X-Ray crystallographic analysis of the corresponding N-(S)-(+)-camphorsulfon yl derivative.