IMMUNOMODULATORY ACTION OF PROPOLIS .5. ANTICOMPLEMENTARY ACTIVITY OFA WATER-SOLUBLE DERIVATIVE

The effect of a water-soluble derivative (WSD) of propolis on the clas sical pathway (CP) and the alternative (AP) complement activity has be en investigated. The in vitro experiments show that WSD inhibits both pathways and the effect depends on the source of complement. The suppr ession of complement-mediated haemolysis proves to be time- and temper ature-related. High WSD concentrations cause direct damage of the targ et erythrocytes. The estimation of C3-residual activity indicates that the preparation diminishes C3 functional activity.